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Cayman GNE-2861
List Price
$334.00
Your Price
$334.00
Cayman GNE-2861 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-29458-5
MFG.PART:
29458-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GNE-2861 is an inhibitor of the group 2 p21-activated kinases (PAKs; IC50s = 7.5, 126, and 36 nM for PAK4, -5, and -6, respectively). It is selective for group 2 PAKs over group 1 PAKs (IC50s = 5.42, 0.97, and >10 μM for PAK1, -2, and -3, respectively), as well as JAK3, KHS1, MAP4K4, and MINK1 at 1 μM. GNE-2861 (0.1-50 μM) inhibits cell migration and reduces cell viability of MDA-MB-436 and MCF-10A PIK3CA cells in a concentration-dependent manner. It sensitizes drug-resistant MCF-7/LCC2 breast cancer cells to tamoxifen (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[2-[1-(2-
CAS Number
1394121-05-1
Molecular Formula
C22H26N6O2
Formula Weight
406.5
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 100 mm
- Ethanol: 100 mm
SMILES
COCCNC1=NC2=CC=C(C#CC3(O)CCCCC3)C=C2N1C4=NC(N)=NC=C4
InChi Code
InChI=1S/C22H26N6O2/c1-30-14-13-25-21-26-17-6-5-16(7-11-22(29)9-3-2-4-10-22)15-18(17)28(21)19-8-12-24-20(23)27-19/h5-6,8,12,15,29H,2-4,9-10,13-14H2,1H3,(H,25,26)(H2,23,24,27)
InChi Key
RZXMIHOUHYSGJO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29458-5 |
|---|---|
| Supplier Part Number | 29458-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1394121-05-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |