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Cayman AZ 12216052
List Price $42.00 Your Price $42.00
Cayman AZ 12216052 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29460-1
MFG.PART: 29460-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[(4-bromo
CAS Number
1290628-31-7
Molecular Formula
C19H22BrNOS
Formula Weight
392.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: soluble
λmax
230, 248 nm
SMILES
BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1
InChi Code
InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,21,22)
InChi Key
QKUYZJOTWYRWNF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29460-1 |
|---|---|
| Supplier Part Number | 29460-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1290628-31-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |