Cayman NVP-CGM097

NVP-CGM097 is an inhibitor of the protein-protein interaction between murine double minute 2 (MDM2) and p53 (IC₅₀ = 1.7 nM for human MDM2 in a TR-FRET assay). It is selective for human MDM2 (K_i = 1.3 nM) over dog, mouse, and rat Mdm2 (K_is = 20.5, 65.9, and 47.4 nM, respectively). NVP-CGM097 selectively inhibits proliferation of acute myeloid leukemia (AML) cells expressing wild-type p53 (IC₅₀s = 50-1,000 nM) over AML cells expressing mutant p53 (IC₅₀s = >1,000 nM). It induces tumor regression in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 100 mg/kg per day.

WARNING This product is not for human or veterinary use.