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Cayman 12-keto Lithocholic Acid
List Price $427.00 Your Price $427.00
Cayman 12-keto Lithocholic Acid - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29547-50
MFG.PART: 29547-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA; Item Nos. 20756 | 18231).1,2 Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Item No. 20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol (Item No. 9003100), hyodeoxycholic acid (HDCA; Item No. 20294), or lithocholic acid (LCA; Item No. 20253).2 12-keto Lithocholic acid activates the human pregnane X receptor (PXR; EC50 = 31.3 μM in a cell-based transactivation assay).3 12-keto Lithocholic acid levels are increased in duodenal bile from patients with type 2 diabetes.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3α,5β)-3-
CAS Number
5130-29-0
Synonyms
- 12-keto LCA
- 12-keto Lithocholate
- 12-KLCA
- 12-oxo LCA
- 12-oxo Lithocholate
- 12-oxo Lithocholic Acid
Molecular Formula
C24H38O4
Formula Weight
390.6
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]([C@]21C)([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O
InChi Code
InChI=1S/C24H38O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,23+,24-/m1/s1
InChi Key
CVNYHSDFZXHMMJ-VPUMZWJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29547-50 |
|---|---|
| Supplier Part Number | 29547-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 5130-29-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |