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Cayman TP-3654
List Price
$118.00
Your Price
$118.00
Cayman TP-3654 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-29571-10
MFG.PART:
29571-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively). It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
trans-α,α-
CAS Number
1361951-15-6
Molecular Formula
C22H25F3N4O
Formula Weight
418.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 16 mg/mL
- DMSO: 16 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 10 mg/mL
λmax
217, 274, 342 nm
SMILES
CC(C)(O)[C@H]1CC[C@H](NC2=NN3C(C=C2)=NC=C3C4=CC=CC(C(F)(F)F)=C4)CC1
InChi Code
InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
InChi Key
XRNVABDYQLHODA-JCNLHEQBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29571-10 |
|---|---|
| Supplier Part Number | 29571-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1361951-15-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |