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Cayman Hypotaurine
Product Description
Hypotaurine is an endogenous inhibitory amino acid. It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 μM). It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM). It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays. Hypotaurine (1 mm) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.
WARNING This product is not for human or veterinary use.
Technical Information
- PBS (pH 7.2): 10 mg/mL
Shipping & Storage Information
| SKU | CAYM-29614-100 |
|---|---|
| Supplier Part Number | 29614-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 300-84-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |