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Cayman XMD8-85
List Price $329.00 Your Price $329.00
Cayman XMD8-85 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29662-50
MFG.PART: 29662-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
XMD8-85 is an ERK5 inhibitor (IC50 = 87 nM in an enzyme assay).1 It is selective for ERK5 over tyrosine non-receptor kinase 2 (TNK2; IC50 = 959 nM), but does inhibit the leucine-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S (IC50 = 26 nM), which has been found in patients with Parkinson’s disease.2,1 XMD8-85 inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50 = 0.19 μM).1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5,11-dihydro-
CAS Number
1234479-76-5
Synonyms
- ERK5-IN-1
Molecular Formula
C25H29N7O2
Formula Weight
459.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10mg/mL
- DMSO: 15mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
- Ethanol: 2mg/mL
λmax
291 nm
SMILES
CN1CCN(C2=CC(OC)=C(NC3=NC=C(N(C)C(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1
InChi Code
InChI=1S/C25H29N7O2/c1-29-11-13-32(14-12-29)17-9-10-19(22(15-17)34-4)27-25-26-16-21-23(28-25)30(2)20-8-6-5-7-18(20)24(33)31(21)3/h5-10,15-16H,11-14H2,1-4H3,(H,26,27,28)
InChi Key
DDTPGANIPBKTNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29662-50 |
|---|---|
| Supplier Part Number | 29662-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1234479-76-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |