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Cayman JPH203
List Price $39.00 Your Price $39.00
Cayman JPH203 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29715-1
MFG.PART: 29715-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter). It is selective for LAT1 over LAT2 (IC50 = >10 μM). JPH203 inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mm. JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
O-[(5-amino-
CAS Number
1037592-40-7
Synonyms
- KYT-0353
Molecular Formula
C23H19Cl2N3O4
Formula Weight
472.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 1 mg/mL
- DMSO:PBS (pH 7.2) (1:4): 0.20 mg/mL
λmax
277 nm
SMILES
NC1=CC(COC2=C(Cl)C=C(C[C@H](N)C(O)=O)C=C2Cl)=C3C(N=C(C4=CC=CC=C4)O3)=C1
InChi Code
InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
InChi Key
XNRZJPQTMQZBCE-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29715-1 |
|---|---|
| Supplier Part Number | 29715-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1037592-40-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |