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Cayman SID 3712249
List Price $103.00 Your Price $103.00
Cayman SID 3712249 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29723-5
MFG.PART: 29723-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SID 3712249 inhibits the biogenesis of microRNA-544 (miR-544), a silencer of mammalian target of rapamycin (mTOR). Under hypoxic conditions, SID 3712249 (20 nM) increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, hypoxia-inducible factor-1α (HIF-1α), and ataxia-telangiectasia mutated kinase (ATM) in MDA-MB-231, MCF-7, and MCF-10A cells. It induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner when used at a concentration of 20 nM. SID 3712249 (20 nM) enhances the sensitivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to decreases in cell viability induced by 5-fluorouracil (5-FU; Item No. ). It reduces tumor growth in an MDA-MB-231 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,8-diamino-
CAS Number
522606-67-3
Molecular Formula
C17H21N7
Formula Weight
323.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:4): 0.2 mg/mL
λmax
299 nm
SMILES
NC1=NC(N2CCCC2)=C(C#N)C3=C1C(N)=NC(N4CCCC4)=C3
InChi Code
InChI=1S/C17H21N7/C18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
InChi Key
SSWVPYMSHHEYAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29723-5 |
|---|---|
| Supplier Part Number | 29723-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 522606-67-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |