Cayman TC-FPR 43

TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).^, TC-FPR 43 induces calcium flux in CHO Cells expressing human FPR2, g_α15, and aequorin (EC₅₀ = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, g_α16, and aequorin in a concentration-dependent manner. TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Item No. ) or IL-8 with IC₅₀ values of 0.64 and 0.24 µM, respectively. It also reduces ear swelling induced by prostaglandin E₂ (PGE₂; Item No. ) and leukotriene B₄ (LTB₄; Item No. ) in mice when administered at a dose of 50 mg/kg.

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