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Cayman IQ-1S (free acid)
List Price
$117.00
Your Price
$117.00
Cayman IQ-1S (free acid) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-29851-5
MFG.PART:
29851-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
IQ-1S (free acid) is an inhibitor of NF-κB/AP-1 (IC50 = 2.3 µM in a reporter assay). It inhibits TNF-α and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM, respectively) and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 2.6 and 5.6 µM, respectively), as well as nitric oxide (NO) production in murine J774-A.1 macrophages (IC50 = 3.1 µM). IQ-1S (free acid) binds to JNKs (Kd = 0.24, 0.36, and 0.1µM for JNK1-3), as well as casein kinase 1δ (CK1δ), PI3Kγ, and MAPK-interacting serine/threonine kinase 2 (MKNK2; Kds = 0.38, 0.47, and 0.92 µM, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
11H-indeno[1,
CAS Number
23146-22-7
Synonyms
- IQ-1
Molecular Formula
C15H9N3O
Formula Weight
247.3
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 15mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.3mg/mL
- DMSO: 10mg/mL
SMILES
O/N=C1C2=C(C=CC=C2)C3=NC4=CC=CC=C4N=C3\1
InChi Code
InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,19H/b18-14+
InChi Key
SZHHSFHOIDCNLD-NBVRZTHBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29851-5 |
|---|---|
| Supplier Part Number | 29851-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 23146-22-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |