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Cayman Ralinepag
List Price $41.00 Your Price $41.00
Cayman Ralinepag - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30009-1
MFG.PART: 30009-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Ralinepag is a prostaglandin I2 (PGI2) receptor (IP) agonist (Ki = 3 nM). It is selective for IP over the PGD2 receptor (DP1) and the PGE2 receptor subtypes EP1-4 (Kis = 2,600, 9,600, 611, 143, and 678 nM, respectively, in radioligand binding assays). Ralinepag induces cAMP accumulation in CHO-K1 cells expressing human recombinant IP (EC50 = 8.5 nM). In vivo, ralinepag (30 mg/kg) prevents increases in pulmonary arterial pressure and vessel wall thickness in a rat model of monocrotaline-induced pulmonary arterial hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[trans-4-
CAS Number
1187856-49-0
Molecular Formula
C23H26ClNO5
Formula Weight
431.9
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 15mg/mL
- DMF:PBS (pH 7.2) (1:8): 0.11mg/mL
- DMSO: 10mg/mL
- Ethanol: 10mg/mL
SMILES
O=C(OC[C@@H]1CC[C@@H](COCC(O)=O)CC1)N(C2=CC=C(Cl)C=C2)C3=CC=CC=C3
InChi Code
InChI=1S/C23H26ClNO5/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27)/t17-,18-
InChi Key
NPDKXVKJRHPDQT-IYARVYRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30009-1 |
|---|---|
| Supplier Part Number | 30009-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1187856-49-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |