We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Abacavir-d4
List Price
$129.00
Your Price
$129.00
Cayman Abacavir-d4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30076-500
MFG.PART:
30076-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir (Item No. ) by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3-azido-3-deoxythymidine (zidovudine; Item No. ) or 2,3-dideoxyinosine (didanosine; Item No. ), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1S,4R)-4-[2-
CAS Number
1260619-56-4
Molecular Formula
C14H14D4N6O
Formula Weight
290.4
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility
- Acetonitrile:Methanol (1:1): soluble
- DMSO: soluble
SMILES
NC1=NC(N([C@@]2([H])C=C[C@@H](CO)C2)C=N3)=C3C(NC4C([2H])([2H])C4([2H])[2H])=N1
InChi Code
InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1/i2D2,3D2
InChi Key
MCGSCOLBFJQGHM-ZOTQTBSBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30076-500 |
|---|---|
| Supplier Part Number | 30076-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1260619-56-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |