Cayman -Substance P (trifluoroacetate salt)

Name: Cayman Sar9, Met(O2)11-Substance P (trifluoroacetate salt)
SKU: CAYM-30106-1
Price: 148.00 USD

List Price $148.00 Your Price $148.00

Cayman [Sar9, Met(O2)11]-Substance P (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-30106-1

MFG.PART: 30106-1

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

[Sar⁹, Met(O₂)¹¹]-Substance P (Sar-SP) is a peptide agonist of the neurokinin-1 (NK₁) receptor. It is selective for NK₁ over NK₂ and NK₃ receptors. Sar-SP induces inositol phosphate formation in U373MG glioblastoma cells with an EC₅₀ value of 3.8 nM, an effect that can be blocked by the NK₁ receptor antagonist SR 140333. It induces contractions in isolated human bronchi when used at concentrations of 3, 100, and 1,000 nM. Sar-SP (10, 25, 65, and 100 pmol/animal, i.c.v.) increases mean arterial pressure and heart rate in conscious rats.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

(S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N¹-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylsulfonyl)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)(methyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide

Synonyms

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O₂]-NH₂

Molecular Formula

C₆₄H₁₀₀N₁₈O₁₅S • XCF₃COOH

Formula Weight

1393.7

Purity

≥95%

Formulation

A solid

Solubility

Water: 1 mg/mL

SMILES

O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N(C)CC(N[C@@H](CC(C)C)C(N[C@@H](CCS(C)(=O)=O)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(C([C@@H](NC([C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4)=O)CCCCN)=O)CCC3.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C64H100N18O15S.C2HF3O2/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71;3-2(4,5)1(6)7/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72);(H,6,7)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-;/m0./s1

InChi Key

VDZDOTCGVUBCPG-LYQMAKBCSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-30106-1
Supplier Part Number	30106-1
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Y
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	5
Hazardous	N
Energy Star	No
Green	No
Controlled	N

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NETA PART NO.	Quantity

Cayman -Substance P (trifluoroacetate salt)

Product Description

Technical Information

Shipping & Storage Information

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