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Cayman MSA-2
List Price
$36.00
Your Price
$36.00
Cayman MSA-2 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30140-1
MFG.PART:
30140-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MSA-2 is an agonist of stimulator of interferon genes (STING). It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 23-cGAMP (Item No. ) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively. It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.
WARNING This product is not for human or veterinary use.
Technical Information
CAS Number
129425-81-6
Synonyms
- 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid
Molecular Formula
C14H14O5S
Formula Weight
294.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 1 mg/mL
λmax
213, 238, 324 nm
SMILES
COC1=C(OC)C=C(C=C(C(CCC(O)=O)=O)S2)C2=C1
InChi Code
InChI=1S/C14H14O5S/c1-18-10-5-8-6-13(9(15)3-4-14(16)17)20-12(8)7-11(10)19-2/h5-7H,3-4H2,1-2H3,(H,16,17)
InChi Key
APCLRHPWFCQIMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-30140-1 |
|---|---|
| Supplier Part Number | 30140-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 129425-81-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |