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Cayman Nateglinide-d5
List Price $262.00 Your Price $262.00
Cayman Nateglinide-d5 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30151-1
MFG.PART: 30151-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Nateglinide-d5 is intended for use as an internal standard for the quantification of nateglinide (Item No. 23320) by GC- or LC-MS. Nateglinide is a hypoglycemic agent.,, It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM. Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice. It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[trans-4-
CAS Number
1227666-13-8
Molecular Formula
C19H22D5NO3
Formula Weight
322.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility
- Chloroform: slightly soluble
- Methanol: slightly soluble
SMILES
CC(C)[C@H]1CC[C@H](C(N[C@H](CC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(O)=O)=O)CC1
InChi Code
InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1/i3D,4D,5D,6D,7D
InChi Key
OELFLUMRDSZNSF-LYGNPMIWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30151-1 |
|---|---|
| Supplier Part Number | 30151-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1227666-13-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |