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Cayman WS-12
List Price
$922.00
Your Price
$922.00
Cayman WS-12 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30352-100
MFG.PART:
30352-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8).1 It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 µM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mm. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin (Item Nos. 92350 | 10010743) in wild-type, but not Trpm8-/-, mice.2 It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R,2S,5R)-N-
CAS Number
68489-09-8
Molecular Formula
C18H27NO2
Formula Weight
289.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 5 mg/mL
λmax
251 nm
SMILES
C[C@@H]1CC[C@@H](C(C)C)[C@H](C(NC2=CC=C(OC)C=C2)=O)C1
InChi Code
InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1
InChi Key
HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30352-100 |
|---|---|
| Supplier Part Number | 30352-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 68489-09-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |