Cayman SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (human IgG1 Fc-tagged)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.^,,,, The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion. It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.^, The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.^,, In this way, ACE2 acts as the functional receptor for SARS-CoV-2. Cayman’s SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (human IgG1 Fc-tagged) protein can be used as an antigen or for Western blot, ELISA, protein-protein interaction studies, and other in vitro binding and in vivo functional assays.

WARNING This product is not for human or veterinary use.