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Cayman 14-Anhydrodigitoxigenin
List Price
$57.00
Your Price
$57.00
Cayman 14-Anhydrodigitoxigenin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30439-5
MFG.PART:
30439-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively) in a panel of 402 kinases. It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic leukemia protein (PML), and PML-dependent activation of p21. XMD8-92 inhibits AP-1 transcriptional activity induced by MEK5-activated ERK5 but not that induced by Cdc37. It inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice and reduces tumor growth in a HeLa mouse xenograft model when administered at a dose of 50 mg/kg twice per day. XMD8-92 also binds bromodomain-containing protein 4 (BRD4; Kd = 170 nM for BRD4 bromodomain 1).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[2-ethoxy-4-(4-hydroxy-
CAS Number
1234480-50-2
Molecular Formula
C26H30N6O3
Formula Weight
474.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- :
- DMF: 1 mg/ml
- DMSO: 1 mg/ml
- Ethanol: 1 mg/ml
λmax
210, 293 nm
SMILES
OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1
InChi Code
InChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29)
InChi Key
QAPAJIZPZGWAND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30439-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 30439-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 4321-20-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |