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Cayman GS-441524
List Price $85.00 Your Price $85.00
Cayman GS-441524 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30469-10
MFG.PART: 30469-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GS-441524 is an antiviral nucleoside analog and a metabolite of remdesivir (Item No. 30354).1 Upon entry into cells, GS-441524 is metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases. It is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 µM, respectively). GS-441524 reduces viral plaque formation in SARS-CoV-2-infected Vero E6 and Calu-3 2B4 cells (EC50s = 0.42 and 0.62 mm, respectively).2 It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 µM, respectively).3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-C-(4-amino
CAS Number
1191237-69-0
Molecular Formula
C12H13N5O4
Formula Weight
291.3
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL
λmax
247 nm
SMILES
NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@H](O)[C@H](O)[C@@H](CO)O3
InChi Code
InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
InChi Key
BRDWIEOJOWJCLU-LTGWCKQJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30469-10 |
|---|---|
| Supplier Part Number | 30469-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1191237-69-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |