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Cayman CAY10760
List Price $340.00 Your Price $340.00
Cayman CAY10760 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30532-5
MFG.PART: 30532-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA). It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-chloro-3-
CAS Number
391889-85-3
Molecular Formula
C28H24ClN3O3
Formula Weight
486.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 11mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.3mg/mL
- DMSO: 10mg/mL
λmax
234 nm
SMILES
O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C4=NN(C(CC)=O)C(C5=CC=C(OC)C=C5)C4
InChi Code
InChI=1S/C28H24ClN3O3/c1-3-25(33)32-24(17-9-12-20(35-2)13-10-17)16-23(31-32)27-26(18-7-5-4-6-8-18)21-15-19(29)11-14-22(21)30-28(27)34/h4-15,24H,3,16H2,1-2H3,(H,30,34)
InChi Key
LAVOKBSCOSIGER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30532-5 |
|---|---|
| Supplier Part Number | 30532-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 391889-85-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |