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Cayman AES-350
List Price
$268.00
Your Price
$268.00
Cayman AES-350 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30607-1
MFG.PART:
30607-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AES-350 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.605, 0.187, and 0.245 µM for HDAC1, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.0244 and 0.899 µM for HDAC6 and HDAC10, respectively). It is selective for class I and class IIb HDACs over HDAC2, -4, -5, -7, -9, and -11 (IC50s = >1 µM for all). AES-350 is cytotoxic to MV4-11, MOLM-13, and MRC-9 cells (IC50s = 0.576, 6, and 33.2 µM, respectively). It induces apoptosis in MV4-11 cells in a concentration-dependent manner.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[4-(1,1-
CAS Number
847249-57-4
Molecular Formula
C18H20N2O3
Formula Weight
312.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 1 mg/mL
λmax
283 nm
SMILES
CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1
InChi Code
InChI=1S/C18H20N2O3/c1-18(2,3)14-8-4-12(5-9-14)16(21)19-15-10-6-13(7-11-15)17(22)20-23/h4-11,23H,1-3H3,(H,19,21)(H,20,22)
InChi Key
FMOQHLZNJFXULZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30607-1 |
|---|---|
| Supplier Part Number | 30607-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 847249-57-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |