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Cayman YM-90K (hydrochloride hydrate)
List Price $198.00 Your Price $198.00
Cayman YM-90K (hydrochloride hydrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30683-5
MFG.PART: 30683-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
YM-90K is an AMPA receptor antagonist (Ki = 0.084 μM in a radioligand binding assay using rat brain membranes).1 It is selective for AMPA over kainate, NMDA-sensitive glutamate, and strychnine-insensitive glycine receptors (Kis = 2.2, >100, and 37 μM, respectively). Intrastriatal administration of YM-90K inhibits AMPA-induced decreases in choline acetyltransferase (ChAT) activity in rat striatum ex vivo in a dose-dependent manner. It inhibits audiogenic seizures in susceptible DBA/2 mice with a minimum effective dose of 3 mg/kg when administered intraperitoneally. Intravenous infusion of YM-90K (20 mg/kg per hour for 4 hours) reduces infarct size in a rat model of focal cerebral ischemia induced by thrombotic middle cerebral artery occlusion (MCAO) in rats.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,4-dihydro-
Molecular Formula
C11H7N5O4 • HCl [XH2O]
Formula Weight
309.7
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: 5 mg/mL
SMILES
O=C(N1)C(NC(C1=C2)=CC([N+]([O-])=O)=C2N3C=NC=C3)=O.Cl.O
InChi Code
InChI=1S/C11H7N5O4.ClH.H2O/c17-10-11(18)14-7-4-9(16(19)20)8(3-6(7)13-10)15-2-1-12-5-15;;/h1-5H,(H,13,17)(H,14,18);1H;1H2
InChi Key
NPEZQTYOSAYJTA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30683-5 |
|---|---|
| Supplier Part Number | 30683-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |