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Cayman Mitiglinide (calcium salt)
List Price $149.00 Your Price $149.00
Cayman Mitiglinide (calcium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30693-100
MFG.PART: 30693-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Mitiglinide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel KIR6.2 (IC50 = 4 nM). It is selective for SUR1/KIR6.2 over SUR2A/KIR6.2 and SUR2B/KIR6.2 channels (IC50s = 3 and 5 µM, respectively). Mitiglinide induces insulin release in HIT-T15 insulinoma cells and isolated mouse pancreatic islets when used at a concentration of 100 µM. Oral administration of mitiglinide (1, 3, and 10 mg/kg) increases postprandial plasma insulin levels and inhibits postprandial increases in plasma glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(αS,3aR,7aS)-
CAS Number
145525-41-3
Synonyms
- KAD-1229
- S21403
Molecular Formula
C19H24NO3 • 1/2Ca
Formula Weight
334.4
Purity
≥98% (mixture of isomers)
Formulation
A crystalline solid
Solubility
- Chloroform: slightly soluble
- DMF: slightly soluble
- DMSO: slightly soluble
- Methanol: slightly soluble
λmax
239 nm
SMILES
O=C(C[C@H](CC1=CC=CC=C1)C([O-])=O)N2C[C@@]3([H])CCCC[C@@]3([H])C2.O=C(C[C@H](CC4=CC=CC=C4)C([O-])=O)N5C[C@@]6([H])CCCC[C@@]6([H])C5.[Ca+2]
InChi Code
InChI=1S/2C19H25NO3.Ca/c2*21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;/h2*1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);/q;;+2/p-2/t2*15-,16+,17-;/m00./s1
InChi Key
PMRVFZXOCRHXFE-FMEJWYFOSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30693-100 |
|---|---|
| Supplier Part Number | 30693-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 145525-41-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |