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Cayman Arenobufagin
List Price $69.00 Your Price $69.00
Cayman Arenobufagin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30695-1
MFG.PART: 30695-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.,,, It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM. Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells. It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model. Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3β,5β,11α)-3,
CAS Number
464-74-4
Molecular Formula
C24H32O6
Formula Weight
416.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:8): 0.11 mg/mL
λmax
299 nm
SMILES
O[C@H]1CC[C@@]2(C)[C@@](CC[C@]([C@]3(O)[C@@]4(C)[C@](C5=COC(C=C5)=O)([H])CC3)([H])[C@]2([H])[C@H](O)C4=O)([H])C1
InChi Code
InChI=1S/C24H32O6/c1-22-9-7-15(25)11-14(22)4-5-17-19(22)20(27)21(28)23(2)16(8-10-24(17,23)29)13-3-6-18(26)30-12-13/h3,6,12,14-17,19-20,25,27,29H,4-5,7-11H2,1-2H3/t14-,15+,16-,17-,19-,20+,22+,23+,24+/m1/s1
InChi Key
JGDCRWYOMWSTFC-AZGSIFHYSA-N
Origin
Plant/Bufonis Venenum
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30695-1 |
|---|---|
| Supplier Part Number | 30695-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 464-74-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |