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Cayman Tolbutamide-d9
List Price $633.00 Your Price $633.00
Cayman Tolbutamide-d9 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30738-10
MFG.PART: 30738-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. 19888) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel KIR6.2 (IC50 = 4.9 µM).1 It is selective for SUR1/KIR6.2 over SUR2A/KIR6.2 and SUR2B/KIR6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.2 In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).3 Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(butyl-
CAS Number
1219794-57-6
Synonyms
- D 860-d9
- U-2043-d9
Molecular Formula
C12H9D9N2O3S
Formula Weight
279.4
Purity
≥99% deuterated forms (d1-d9)
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/mL
SMILES
CC1=CC=C(S(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)(=O)=O)C=C1
InChi Code
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)/i1D3,3D2,4D2,9D2
InChi Key
JLRGJRBPOGGCBT-ZYWCKPJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30738-10 |
|---|---|
| Supplier Part Number | 30738-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1219794-57-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |