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Cayman ZL0420
List Price $240.00 Your Price $240.00
Cayman ZL0420 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30741-10
MFG.PART: 30741-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ZL0420 is an inhibitor of bromodomain 1 (BD1) and BD2 in bromodomain-containing protein 4 (BRD4; IC50s = 27 and 32 nM, respectively). It is selective for BD1 and BD2 in BRD4 over BD1 in BRD2, BRD3, and BRDT (IC50s = 803, 2,275, and 3,183 nM, respectively) and BD2 (IC50s = 1,736, 2,193, and 2,781 nM, respectively), as well as the bromodomain in CBP (IC50 = >10,000 nM). ZL0420 inhibits the expression of interferon-stimulated gene 54 (ISG54), ISG56, IL-8, and growth-regulated protein β (Groβ) induced by the toll-like receptor 3 (TLR3) agonist poly(I:C) by approximately 95% in human small airway epithelial cells. It also inhibits neutrophil infiltration around small- and medium-sized airways and reduces cytokine expression in lung tissue in a poly(I:C)-induced mouse model of acute airway inflammation when administered at a dose of 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[2-(2-amino-
CAS Number
2229039-45-4
Molecular Formula
C16H16N4O2
Formula Weight
296.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:9): 0.1 mg/mL
λmax
269, 349, 448 nm
SMILES
OC1=C(C)C=C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)C(N)=C1
InChi Code
InChI=1S/C16H16N4O2/c1-9-6-14(12(17)8-15(9)21)20-19-11-3-4-13-10(7-11)2-5-16(22)18-13/h3-4,6-8,21H,2,5,17H2,1H3,(H,18,22)/b20-19+
InChi Key
ANMQADUROYWADA-FMQUCBEESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30741-10 |
|---|---|
| Supplier Part Number | 30741-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2229039-45-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |