Cayman Succinobucol

Succinobucol is a metabolically stable derivative of probucol (Item No. ) with diverse biological activities.^,, It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H₂DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM. Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells. Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys. It also inhibits the formation of aortic atherosclerotic plaques in ApoE^-/- or Ldlr^-/- mice.

WARNING This product is not for human or veterinary use.