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Cayman CLP 257
List Price
$36.00
Your Price
$36.00
Cayman CLP 257 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30948-1
MFG.PART:
30948-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CLP 257 is a K+/Cl- cotransporter 2 (KCC2) activator.,, It induces chloride transport in NG108-cl cells that endogenously express low levels of KCC2 (EC50 = 616 nM). It is selective for KCC2 over GABAA receptors at 50 µM. CLP 257 (25 µM) increases the rate of chloride accumulation in spinal slices isolated from a rat model of peripheral nerve injury and BDNF control slices, which exhibit reduced levels of KCC2. In vivo, CLP 257 (100 mg/kg) increases mechanical and withdrawal thresholds in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(5Z)-5-[(4-
CAS Number
1181081-71-9
Molecular Formula
C14H14FN3O2S
Formula Weight
307.3
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 20 mg/mL
SMILES
FC1=CC=C(/C=C2SC(N3NCCCC3)=NC\2=O)C(O)=C1
InChi Code
InChI=1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChi Key
SKCADXVKQRCWTR-GHXNOFRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30948-1 |
|---|---|
| Supplier Part Number | 30948-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1181081-71-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |