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Cayman AS-2863619
List Price
$134.00
Your Price
$134.00
Cayman AS-2863619 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30976-1
MFG.PART:
30976-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively). It induces Foxp3 expression in isolated mouse naïve T cells when used at a concentration of 1 µM alone or synergistically in combination with TGF-β. AS-2863619 (30 mg/kg) decreases ear edema and induces production of Foxp3+ regulatory T cells (Tregs) in mice. It also reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[1-(2-methyl-
CAS Number
2241300-51-4
Molecular Formula
C16H12N8O • 2HCl
Formula Weight
405.2
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 10 mm
SMILES
NC1=NON=C1C2=NC(C=NC=C3)=C3N2C4=CC=C(N=C(C)N5)C5=C4.Cl.Cl
InChi Code
InChI=1S/C16H12N8O.2ClH/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14;;/h2-7H,1H3,(H2,17,23)(H,19,20);2*1H
InChi Key
LHUAALWRORLTCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30976-1 |
|---|---|
| Supplier Part Number | 30976-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2241300-51-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |