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Cayman Alarelin (acetate)
List Price
$385.00
Your Price
$385.00
Cayman Alarelin (acetate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-30993-100
MFG.PART:
30993-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Alarelin is a peptide agonist of gonadotropin-releasing hormone (GnRH). It binds to the GnRH receptor (GnRHR) with a Kd value of 0.2 nM. Alarelin (6 ng, i.c.v.) decreases the expression of GnRH in the preoptic area and GnRHR in the posterior mediobasal hypothalamus (pMBH) of ovariectomized estradiol-treated rats, indicating an ultrashort negative feedback loop on GnRH and GnRHR gene expression. It induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats. Alarelin reduces tumor growth in an HEC-1-B human endometrial carcinoma mouse xenograft model when administered at doses of 20, 40, and 80 µg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-D-alanine-9-
CAS Number
79561-22-1
Synonyms
- pGlu-HWSYALRP-NHEt
- [D-Ala6, des-Gly10]GnRH-ethylamide
- des-Gly GnRH
Molecular Formula
C56H78N16O12 • 2C2H4O2
Formula Weight
1287.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- PBS (pH 7.2): 5 mg/mL
λmax
221 nm
SMILES
O=C(N[C@@H](CO)C(N[C@H](C(N[C@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N(CCC1)[C@@H]1C(NCC)=O)=O)=O)=O)=O)CC(C=C2)=CC=C2O)=O)[C@@H](NC([C@@H](NC([C@H](CC3)NC3=O)=O)CC4=CN=CN4)=O)CC5=CNC6=CC=CC=C56.CC(O)=O.CC(O)=O
InChi Code
InChI=1S/C56H78N16O12.2C2H4O2/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;2*1-2(3)4/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);2*1H3,(H,3,4)/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1
InChi Key
DPWSRXJWCYEGIV-PFHUABGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30993-100 |
|---|---|
| Supplier Part Number | 30993-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 79561-22-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |