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Cayman ICEC0942 (hydrochloride)
List Price $92.00 Your Price $92.00
Cayman ICEC0942 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-30997-1
MFG.PART: 30997-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM).1 It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the g2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10 µM. In vivo, ICEC0942 (100 mg/kg) reduces tumor growth in MCF-7 and HCT116 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3R,4R)-4-
CAS Number
1805789-54-1
Molecular Formula
C22H30N6O • HCl
Formula Weight
431.0
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: Soluble
λmax
245 nm
SMILES
O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C=NN3C(NCC4=CC=CC=C4)=C2)C(C)C.Cl
InChi Code
InChI=1S/C22H30N6O.ClH/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29;/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27);1H/t17-,19+;/m1./s1
InChi Key
YMNPLAHCOLEZJE-ZFNKBKEPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30997-1 |
|---|---|
| Supplier Part Number | 30997-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1805789-54-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |