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Cayman C3001a
List Price
$90.00
Your Price
$90.00
Cayman C3001a - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-31064-1
MFG.PART:
31064-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2. It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a panel of five additional K2P channels at 10 µM. In vivo, C3001a (10 mg/kg) reduces edema and pancreatic necrosis in a mouse model of acute pancreatitis. It reduces mechanical and thermal hyperalgesia in a mouse model of chronic inflammatory pain induced by complete Freunds adjuvant (CFA). C3001a (5 mg/kg) also reduces cold hyperalgesia in a mouse model of neuropathic pain induced by spared nerve injury (SNI).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1S,3R)-3-
CAS Number
2415154-29-7
Molecular Formula
C21H20N2O3S
Formula Weight
380.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL
λmax
215, 330 nm
SMILES
CC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC([C@H]4C[C@@H](C(O)=O)CC4)=O
InChi Code
InChI=1S/C21H20N2O3S/c1-12-2-9-17-18(10-12)27-20(23-17)13-5-7-16(8-6-13)22-19(24)14-3-4-15(11-14)21(25)26/h2,5-10,14-15H,3-4,11H2,1H3,(H,22,24)(H,25,26)/t14-,15+/m1/s1
InChi Key
OUAZWUKQRHZQNC-CABCVRRESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-31064-1 |
|---|---|
| Supplier Part Number | 31064-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2415154-29-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |