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Cayman MLN0905
List Price $55.00 Your Price $55.00
Cayman MLN0905 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31115-1
MFG.PART: 31115-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MLN0905 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM). It inhibits 95% of Plk1 activity but also inhibits the activity of 10 additional kinases by greater than or equal to 90% in a panel of 359 kinases at 1 µM. MLN0905 reduces phosphorylation of histone H3 at serine 10 (H3S10Ph), a marker of cell cycle arrest at prometaphase, in HT-29 colorectal cancer cells (EC30 = 9 nM). It inhibits proliferation in a panel of six human lymphoma cell lines with IC50 values ranging from 3.2 to 24 nM. MLN0905, alone or in combination with rituximab, increases survival in an OCI LY-19 metastatic lymphoma mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[5-[3-
CAS Number
1228960-69-7
Molecular Formula
C24H25F3N6S
Formula Weight
486.6
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: soluble
SMILES
FC(F)(F)C1=CC=C2C(NC(CC3=CN=C(NC4=C(C)N=CC(CCCN(C)C)=C4)N=C32)=S)=C1
InChi Code
InChI=1S/C24H25F3N6S/c1-14-19(9-15(12-28-14)5-4-8-33(2)3)31-23-29-13-16-10-21(34)30-20-11-17(24(25,26)27)6-7-18(20)22(16)32-23/h6-7,9,11-13H,4-5,8,10H2,1-3H3,(H,30,34)(H,29,31,32)
InChi Key
CODBZFJPKJDNDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31115-1 |
|---|---|
| Supplier Part Number | 31115-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1228960-69-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |