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Cayman CCG-215022
List Price $49.00 Your Price $49.00
Cayman CCG-215022 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31120-1
MFG.PART: 31120-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CCG-215022 is a g protein-coupled receptor kinase (GRK) inhibitor (IC50s = 3.9, 0.15, and 0.38 μM for GRK1, GRK2, and GRK5, respectively). It is selective for GRKs over protein kinase A (PKA; IC50 = 120 μM). CCG-215022 (500 nM) increases contractility in isoproterenol-stimulated isolated mouse cardiomyocytes. It prevents the desensitization of histamine H1 receptor- and purinergic P2Y2 receptor-driven phospholipase C signaling in human ULTR myometrial cells and isolated rat mesenteric smooth muscle cells (MSMCs), respectively (IC50s = 3.09 and 2.95 μM, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[4-fluoro-3-
CAS Number
1813527-81-9
Molecular Formula
C26H22FN7O3
Formula Weight
499.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/mL
- DMSO: 1 mg/mL
- DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL
SMILES
O=C1NC(C)=C(C(NC2=CC(C=NN3)=C3C=C2)=O)C(C4=CC(C(NCC5=CC=CC=N5)=O)=C(F)C=C4)N1
InChi Code
InChI=1S/C26H22FN7O3/c1-14-22(25(36)32-17-6-8-21-16(10-17)12-30-34-21)23(33-26(37)31-14)15-5-7-20(27)19(11-15)24(35)29-13-18-4-2-3-9-28-18/h2-12,23H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37)
InChi Key
BLMBNKDQXGINRE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31120-1 |
|---|---|
| Supplier Part Number | 31120-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1813527-81-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |