Cayman Cyclo(L-His-L-Pro)

Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).¹ It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.² It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.^1,3 Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.¹

WARNING This product is not for human or veterinary use.