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Cayman IMP-1710
List Price $203.00 Your Price $203.00
Cayman IMP-1710 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31391-1
MFG.PART: 31391-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
IMP-1710 is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 38 nM in a fluorescence polarization assay) that contains an alkyne moiety for use in click chemistry reactions. It is selective for UCH-L1 over a panel of 20 deubiquitinating enzymes at 1 µM. IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis (IC50 = 740 nM). It has been used for labeling UCH-L1 in cell-based assays, followed by click reactions with azide-modified TAMRA and biotin capture reagents.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-2-[[4-(5-
CAS Number
2383117-96-0
Synonyms
- Click Tag™ IMP-1710
Molecular Formula
C23H19N5O
Formula Weight
381.4
Purity
≥98%
Formulation
A solution in ethanol
Solubility
- Chloroform: 10 mg/mL
- Ethanol: 5 mg/mL
λmax
249 nm
SMILES
O=C([C@H]1N(C#N)CCC1)N2C3=CC=CC(C(C4=C5)=CNC4=NC=C5C#C)=C3CC2
InChi Code
InChI=1S/C23H19N5O/c1-2-15-11-18-19(13-26-22(18)25-12-15)16-5-3-6-20-17(16)8-10-28(20)23(29)21-7-4-9-27(21)14-24/h1,3,5-6,11-13,21H,4,7-10H2,(H,25,26)/t21-/m0/s1
InChi Key
FYMVGXGSNIVSKY-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-31391-1 |
|---|---|
| Supplier Part Number | 31391-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 2383117-96-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |