Cayman Dodecyl Gallate

Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.^1,2,3 It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC₅₀s = 0.8, 1.4, and 17.0 µM, respectively).¹ It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.² It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/mL), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/mL for all), and acts by inhibiting the bacterial membrane respiratory chain.³

WARNING This product is not for human or veterinary use.