Cayman Bobcat 339

Bobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC₅₀s = 33 and 73 µM, respectively, in cell-free assays).¹ However, it was found that the TET inhibitory activity was due to residual copper in the Bobcat 339 preparation used for the experiments.² Copper-containing Bobcat 339 (10 µM) also reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons, but copper-free preparations of Bobcat 339 (50 µM) do not reduce DNA 5-hmC levels in Hep3B cells.^1,2

WARNING This product is not for human or veterinary use.