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Cayman INCB 057643
List Price $263.00 Your Price $263.00
Cayman INCB 057643 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31456-5
MFG.PART: 31456-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
INCB 057643 is a bromodomain and extra terminal domain (BET) family protein inhibitor.1 It inhibits binding of bromodomain-containing protein 2 (BRD2), BRD3, and BRD4 to an acetylated histone H4 peptide in vitro. INCB 057643 decreases Myc levels in, and inhibits proliferation of, acute myeloid leukemia (AML), diffuse large B cell lymphoma (DLBCL), and multiple myeloma (mm) cells. In vivo, INCB 057643 reduces tumor growth in AML, DLBCL, and mm mouse xenograft models. It also reduces tumor growth when administered alone or in combination with docetaxel (Item No. 11637) or enzalutamide (MDV 3100; Item No. 11596) in a 22Rv1 castration-resistant prostate cancer (CRPC) mouse xenograft model.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-(6,7-
CAS Number
1820889-23-3
Molecular Formula
C20H21N3O5S
Formula Weight
415.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.14 mg/mL
λmax
226, 257 nm
SMILES
O=C1C2=C(C(C3=C(OC(C)(C)C(N4C)=O)C4=CC(S(C)(=O)=O)=C3)=CN1C)C=CN2
InChi Code
InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3
InChi Key
VZSAMEOETVNDQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31456-5 |
|---|---|
| Supplier Part Number | 31456-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1820889-23-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |