Cayman R1487 (hydrochloride)

R1487 is an inhibitor of p38α MAPK (IC₅₀ = 10 nM). It is selective for p38α over p38β MAPK (K_ds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by greater than 85% at 10 µM. R1487 inhibits LPS-induced IL-1β production in isolated human whole blood (IC₅₀ = 170 nM). It also inhibits LPS-induced production of TNF-α and IL-6 in rats (ED₅₀s = 0.8 and 0.4 mg/kg). R1487 reduces yeast-induced hyperalgesia in rats (ED₅₀ = 5.5 mg/kg).

WARNING This product is not for human or veterinary use.