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Cayman Valemetostat
List Price $59.00 Your Price $59.00
Cayman Valemetostat - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31674-500
MFG.PART: 31674-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Valemetostat is a dual inhibitor of enhancer of zeste homolog 1 (EZH1) and EZH2.1 It inhibits polycomb repressive complex 2 (PRC2) containing EZH1 or EZH2 as the catalytic subunit in cell-free assays (IC50s = 8.4 and 2.5 nM, respectively). Valemetostat inhibits trimethylation of histone H3 lysine 27 in HCT116 cells (IC50 = 0.44 nM). It inhibits the growth of Karpas-422 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 4.8 nM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2R)-7-chloro-
CAS Number
1809336-39-7
Synonyms
- DS-3201b
- (R)-OR-S2
Molecular Formula
C26H34ClN3O4
Formula Weight
488.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
λmax
216 nm
SMILES
CC1=C2C(O[C@@](O2)([C@]3([H])CC[C@H](CC3)N(C)C)C)=C(C=C1C(NCC4=C(C=C(NC4=O)C)C)=O)Cl
InChi Code
InChI=1S/C26H34ClN3O4/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32)/t17-,18-,26-/m1/s1
InChi Key
SSDRNUPMYCFXGM-UYPAYLBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31674-500 |
|---|---|
| Supplier Part Number | 31674-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1809336-39-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |