Cayman CDDO-IM

CDDO-IM is a synthetic triterpenoid and an activator of Nrf2 signaling.^1,2 It binds to Keap1, inhibiting the degradation of Nrf2 and leading to increased Nrf2 protein levels.² CDDO-IM (100 nM) increases the expression of Nrf2 target genes and activates heme oxygenase-1 (HO-1) in a reporter assay using CV-1 cells.¹ It also binds to PPARγ and PPARα (K_is = 344 and 232 nM, respectively) and induces PPARγ transactivation in SW480 cells.^3,4 It inhibits the production of nitric oxide synthase (NOS) in isolated mouse macrophages (IC₅₀ = 0.014 nM).⁵ CDDO-IM (300 nM) inhibits proliferation of U937 and MCF-7 cells and reduces fatty acid synthesis in LiSa-2 human liposarcoma cells when used at a concentration of 100 nM.^3,6 It reduces tumor growth in a B16 murine melanoma model when administered at a dose of 50 µg/animal twice per day.³

WARNING This product is not for human or veterinary use.