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Cayman RU-521
List Price $167.00 Your Price $167.00
Cayman RU-521 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31765-5
MFG.PART: 31765-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
RU-521 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.11 µM).1 It inhibits dsDNA-, but not IFN-β- or 5ppp-HP20 RNA-, induced IFN-β1-dependent gene expression in reporter assays and does not inhibit Pam3CSK4-, poly(I:C)-, or LPS-induced Il6 mRNA expression in RAW 264.7 cells, indicating selectivity for cGAS-mediated signaling. It reduces basal Ifnb1 mRNA expression in bone marrow-derived macrophages (BMDMs) generated from the Trex1-/- mouse model of Aicardi-Goutières syndrome, an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[1-(6,7-
CAS Number
2262452-06-0
Synonyms
- RU-320521
Molecular Formula
C19H12Cl2N4O3
Formula Weight
415.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.14 mg/mL
λmax
303 nm
SMILES
O=C1OC(C2=C(N(C3=NC4=C(N3)C(Cl)=C(Cl)C=C4)N=C2C)O)C5=C1C=CC=C5
InChi Code
InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,26H,1H3,(H,22,23)
InChi Key
VIQXILLOJLATEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31765-5 |
|---|---|
| Supplier Part Number | 31765-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2262452-06-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |