Cayman Furosemide-d5

Furosemide-d₅ is intended for use as an internal standard for the quantification of furosemide (Item No. ) by GC- or LC-MS. Furosemide is a loop diuretic and an inhibitor of the Na⁺/K⁺/2Cl^- (NKCC) cotransporters, NKCC1 and NKCC2 (K_is = ^~10 µM for both).^, In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs. Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy. It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (K_is = 0.052-0.065 µM) and organic ion transporter 1 (OAT1; K_i = 9.5 µM), as well as a GABA_A receptor antagonist.^,,

WARNING This product is not for human or veterinary use.