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Cayman NP19
List Price $845.00 Your Price $845.00
Cayman NP19 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-31791-10
MFG.PART: 31791-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
NP19 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 12.5 nM in a homogenous time-resolved fluorescence (HTRF) assay).1 It increases IFN-γ production by isolated human peripheral blood mononuclear cells (PBMCs) in co-culture with anti-CD3 single-chain variable fragment- and PD-L1-expressing Hep3B hepatoma cells (EC50 = ~3 µM). NP19 (25, 50, and 100 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model and an H22 murine hepatocellular carcinoma model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[5-chloro-2-
CAS Number
2377916-66-8
Molecular Formula
C33H31ClN2O4
Formula Weight
555.1
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
SMILES
N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC=C4)=C3C)=C(C=C2CNC(C)(C)C(O)=O)Cl)=C1
InChi Code
InChI=1S/C33H31ClN2O4/c1-22-26(13-8-14-28(22)25-11-5-4-6-12-25)21-40-31-17-30(39-20-24-10-7-9-23(15-24)18-35)27(16-29(31)34)19-36-33(2,3)32(37)38/h4-17,36H,19-21H2,1-3H3,(H,37,38)
InChi Key
YZPKZNFXWGTUGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31791-10 |
|---|---|
| Supplier Part Number | 31791-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2377916-66-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |