Cayman SARS-CoV-2 nsp16 Methyltransferase (recombinant)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus and the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.^,,,, The SARS-CoV-2 genome contains approximately 30 kilobases and 14 open reading frames (ORFs) that encode four structural proteins: spike, envelope, membrane, and nucleocapsid, as well as 16 non-structural proteins and 9 accessory factors. SARS-CoV-2 nsp16 methyltransferase (recombinant) is a 2-O-methyltransferase (2-O-MTase) and has a role in 5-end capping of viral mRNAs.^, In coronaviruses, nsp16 forms a complex with nsp10 to methylate nascent mRNAs at the ribose 2-O position, creating a Cap-1 structure that facilitates increased translation of viral mRNAs and reduced innate immune recognition by the host cell.^, Deficiency of nsp16 in the related virus SARS-CoV reduces viral RNA synthesis by approximately 10-fold in vitro, and mutations in the nsp16 KDKE catalytic tetrad in mouse-adapted SARS-CoV attenuate the virus in vivo.^, An nsp10-derived peptide inhibitor of the nsp16/nsp10 complex increases survival in a mouse model of infection with the coronavirus mouse hepatitis virus (MHV). Caymans SARS-CoV-2 nsp16 Methyltransferase (recombinant) protein consists of 299 amino acids and has a calculated molecular weight of 33.46 kDa.

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