Cayman CEACAM8/CD66b (human, recombinant)

CD66b, also known as carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8), is a member of the carcinoembryonic antigen (CEA) family encoded by CEACAM8 in humans.^, It is a single-chain glycoprotein, comprised of N-terminal immunoglobulin (Ig) variable-like (IgV) and Ig constant-like (IgC) domains, that is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) linker. CD66b is expressed exclusively in granulocytes, with neutrophil and eosinophil expression increasing under inflammatory conditions to mediate intercellular adhesion to endothelial cells, signal transduction, and cell activation.^, The percentage of colonic CD66b⁺ neutrophils is increased and positively correlates with endoscopic disease severity in patients with Crohn’s disease. The percentage of CD66b⁺ neutrophils is also increased in gastric cancer tissues and is associated with poor prognosis. Cayman’s CEACAM8/CD66b (human, recombinant) protein can be used for binding assays. The protein consists of 296 amino acids, has a calculated molecular weight of 32.8 kDa, and a predicted N-terminus of Gln35 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 55 to 60 kDa due to glycosylation.

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