Cayman SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody (Clone 08)

Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 nucleocapsid proteins are encoded by the N gene in SARS-CoV and SARS-CoV-2 RNA.^1,2 SARS-CoV and SARS-CoV-2 are members of the Betacoronavirus genus of viruses that have approximately 79% sequence identity and share 27 T cell epitopes in common.^3,4,5 The SARS-CoV-2 nucleocapsid protein has greater than 90% similarity to the SARS-CoV nucleocapsid protein and contains two unique B cell epitopes and two T cell epitopes that are structurally stable, non-allergenic, and induce production of IFN-γ.^5,2 SARS-CoV and SARS-CoV-2 nucleocapsid proteins package the viral RNA into a helical ribonucleoprotein complex (RNP), which is a template for viral replication, and are integral for viral self-assembly and involved in regulation of the host cell cycle.^6,2 SARS-CoV and SARS-CoV-2 are the causative agents of SARS and COVID-19, respectively, both of which are primarily respiratory illnesses characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.^4,7,8 Caymans SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody (Clone 08) can be used for ELISA, flow cytometry (FC), immunohistochemistry-paraffin (IHC-P), and Western blot (WB) applications. The antibody recognizes wild-type and various mutant nucleocapsid proteins at 45.6 kDa from SARS-CoV, SARS-CoV-2, and several SARS-CoV-2 Alpha, Beta, Gamma, Delta, Eta, and Omicron subvariants.

WARNING This product is not for human or veterinary use.