Cayman SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain Polyclonal Antibody

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.^1,2,3,4,5 The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion.¹ It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.^6,7 The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.^8,9,10 Caymans SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain Polyclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes the spike glycoprotein RBD from SARS-CoV-2 and SARS-CoV.

WARNING This product is not for human or veterinary use.